Dr Tatiana BESSET, researcher in the joint research unit COBRA (JRU 6014) between CNRS, INSA Rouen and the University of Rouen, has been rewarded an ERC Starting Grant.
This grant supports promising early career researchers with 2 to 7 years of experience after PhD who have already produced excellent supervised work and who are ready to work independently. The ERC supports researchers who are eager to carry out ground-breaking and ambitious research.
The ERC awards flexible, long-term funding for a period of up to five years.
Thus, with a budget of around € 1.5 million, the ERC will support the development of the project FARCATCH “Innovative Strategies for Unprecedented Remote C-H bond Functionalization by Catalysis”. In this proposal, a general approach to functionalize a CH bond located at a Far position (from a functional group) by Catalysis will be implemented. Designing a full set of tools as Swiss army knife for the selective functionalization at unconventional positions inaccessible so far, can considerably change the way organic molecules are made. These original technologies will offer new synthetic routes to access original sulfur- and fluorine-containing molecules, compounds of interest in drugs discovery, material sciences, pharmaceutical and agrochemical industry.
The ERC will also enable Dr Tatiana BESSET to build her own research team to carry out the FARCATCH project.
- M. Gao, M.-Y. Chen, X. Pannecoucke, P. Jubault, T. Besset,
Chem. Eur. J. 2020, DOI: 10.1002/chem.202003521.
Pd‐Catalyzed Directed Thiocyanation Reaction by C–H Bond Activation
Invited contribution for a "Young Chemists Special Issue”
- E. Nobile, T. Castanheiro, T. Besset
Angew. Chem. Int. Ed. 2020, DOI: 10.1002/ange.202009995.
Radical‐Promoted Distal C‐H Functionalization of C(sp3) Centers with Fluorinated Moieties
- M.-Y. Chen, X. Pannecoucke, P. Jubault, T. Besset
Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c02750.
Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature
- L. Ruyet, T. Besset* Beilstein J.
Org. Chem. 2020, 16, 1051-1065. DOI:10.3762/bjoc.16.92.
Copper-based fluorinated reagents for the construction of CF2R-containing molecules (R ≠ F).
Invited contribution for the “Copper-Catalyzed Reactions for Organic Synthesis” thematic issue of the Beilstein Journal of Organic Chemistry.
- M. Barday, R. Blieck, L. Ruyet, T. Besset*
Tetrahedron 2020, DOI:10.1016/j.tet.2020.131153.
Remote trifluoromethylthiolation of alcohols under visible light.
Invited contribution for the special issue for Nuno Maulide.
- F. Petit-Cancelier, B. François, X. Pannecoucke, S. Couve-Bonnaire, T. Besset*
Adv. Synth. Catal. 2020, 362, 760. DOI:10.1002/adsc.201901454
S-(Diethyl phosphonodifluoromethyl)Benzenesulfonothioate: A New Reagent for the Synthesis of SCF2PO(OEt)2-containing Molecules.
- M.-Y. Chen, X. Pannecoucke, P. Jubault, T. Besset,*
J. Org. Chem. 2019, 84, 13194. DOI: 10.1021/acs.joc.9b01872
Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C−H Bond Activation
Invited contribution for the special issue on "C-H Bond Functionalization."
- J. Wang, H.-Y. Xiong, E. Petit, L. Bailly, X. Pannecoucke, T. Poisson, T. Besset,*
Chem. Commun. 2019, 55, 8784. DOI: 10.1039/C9CC01851D
BiCl3-Mediated Direct Functionalization of Unsaturated C–C Bonds with an Electrophilic SCF2PO(OEt)2 Reagent
- E. Carbonnel, T. Poisson, P. Jubault, X. Pannecoucke, T. Besset,*
Front. Chem. 2019, 7, 111. DOI: 10.3389/fchem.2019
Recent Advances for the Direct Introduction of the CF2Me Moiety
- C. Sambiagio, D. Schönbauer, R. Blieck, T. Dao-Huy, G. Pototschnig, P. Schaaf, T. Wiesinger, M. F. Zia, J. Wencel-Delord, T. Besset, B. U. W. Maes, M. Schnürch
Chem. Soc. Rev. 2018, 47, 6603
A comprehensive overview of directing groups applied in metal catalysed C–H functionalisation chemistry