ERC

Dr Tatiana BESSET, researcher in the joint research unit COBRA (JRU 6014) between CNRS, INSA Rouen and the University of Rouen, has been rewarded an ERC Starting Grant.
This grant supports promising early career researchers with 2 to 7 years of experience after PhD who have already produced excellent supervised work and who are ready to work independently. The ERC supports researchers who are eager to carry out ground-breaking and ambitious research.
The ERC awards flexible, long-term funding for a period of up to five years.
Thus, with a budget of around € 1.5 million, the ERC will support the development of the project FARCATCH “Innovative Strategies for Unprecedented Remote C-H bond Functionalization by Catalysis”. In this proposal, a general approach to functionalize a CH bond located at a Far position (from a functional group) by Catalysis will be implemented. Designing a full set of tools as Swiss army knife for the selective functionalization at unconventional positions inaccessible so far, can considerably change the way organic molecules are made. These original technologies will offer new synthetic routes to access original sulfur- and fluorine-containing molecules, compounds of interest in drugs discovery, material sciences, pharmaceutical and agrochemical industry.

The ERC will also enable Dr Tatiana BESSET to build her own research team to carry out the FARCATCH project.

Click to download the FarCatCH logo

 

 

Members

Publications

J. Vigier, F. Buttard, H. Lebel,* T. Besset,*
Eur. J. Org. Chem. 2024, DOI : 10.1002/ejoc.202301205
C-Centered Radical Intermediates for C(sp3)H Bonds Functionalization: An Emerging Approach towards Alkyl Thiocyanates”

J. Vigier, M. Gao, P. Jubault, H. Lebel,* T. Besset,*
Chem. Commun. 2024, DOI: 10.1039/D3CC04624A.
Divergent process for the catalytic decarboxylative thiocyanation and isothiocyanation of carboxylic acids promoted by visible light.

E. Nobile, F. Doche, T. Castanheiro, D. G. Musaev,* T. Besset,*
Chem. Eur. J. 2023, e202303362. DOI: 10.1002/chem.202303362.
Copper-Catalyzed CH (Phenylsulfonyl)Difluoromethylation of Acrylamides: Scope, Mechanism, and Critical Role of Additives”

F. Doche, T. Poisson, T. Besset,*
ACS Catal. 2023, 13, 14112. DOI: 10.1021/acscatal.3c03249.
Photocatalytic α-Trifluoromethylthiolation of N-Acyl Amines

L. Monsigny, F. Doche, T. Besset,* Beilstein J.
Org. Chem. 2023, 19, 448. DOI: 10.3762/bjoc.19.35
Transition-metal-catalyzed CH bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview.”

F. Buttard*, T. Besset,*
SynOpen 2023, 07, 117. DOI: 10.1055/a-2041-0188.
Emergent Strategies for Catalytic Enantioselective DirectThiocyanation and Selenocyanation reactions.”

F. Doche, J. Esudero, F. Petit-Cancelier, H.-Y. Xiong, S. Couve-Bonnaire, D. Audisio, T. Poisson, T. Besset,*
Chem. Eur. J. 2022, DOI: 10.1002/chem.202202099.
Directed Palladium Catalyzed CH (Ethoxycarbonyl)difluoromethylthiolation Reactions.”

M. Vuagnat, V. Tognetti, P. Jubault, T. Besset,*
Chem. Eur. J. 2022, DOI: 10.1002/chem.202201928.
Ru(II)-Catalyzed Hydroarylation of in situ generated 3,3,3-Trifluoro-1-propyne by CH Bond Activation: A Facile and Practical Access to β-trifluoromethylstyrenes”

E. Nobile, J.-P. Hébert, T. Castanheiro, A. Ledoux, T. Besset,*
Org. Process Res. Dev. 2022, DOI: 10.1021/acs.oprd.2c00099.
Cost-efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents

F. Petit-Cancelier, L. Ruyet, S. Couve-Bonnaire, T. Besset,*
Adv. Synth. Catal. 2022, 364, 1498-1502. DOI: 10.1002/adsc.202200059.
Distal Construction of a Carbon-SCF2R Bond on Aliphatic Alcohols Enabled by 1,5-Hydrogen-Atom Transfer

J. Fichez, D. Dupommier, T. Besset,*
Synthesis, 2022, accepté.
Direct Synthesis of Disubstituted Trifluoromethylthiolated Alkenes (Review)
Invited contribution for the Synthesis Special Issue honoring Prof. Ferenc Fülöp

M. Gao, M. Vuagnat, P. Jubault, T. Besset*
Eur. J. Org. Chem. 2022, e202101255. DOI: 10.1002/ejoc.202101255. Very Important Paper
N-Thiocyanato-2,10-camphorsultam Derivatives: Design and Applications of Original Electrophilic Thiocyanating Reagents
Invited contribution for the Eur. J. Org. Chem. Special Issue honoring Prof. Ferenc Fülöp.

E. Nobile, T. Castanheiro, T. Besset,*
Chem. Commun. 2021, 57, 12337. DOI: 10.1039/d1cc04737j
CH Electrophilic (phenylsulfonyl)difluoromethylation of (hetero)arenes with a newly designed reagent

 

F. Petit-Cancelier, S. Couve-Bonnaire, T. Besset,*
Tetrahedron 2021, 98, 132446. DOI: 10.1016/j.tet.2021.132446
Synthesis of a Library of SCF2CO2Et Reagents: An Access To Original (Ethoxycarbonyl)difluoromethylthioesters
Invitation for a special Issue in Tetrahedron entitled "Fluorine and Chalcogens"

L. Ruyet, T. Poisson, T. Besset,*
Eur. J. Org. Chem. 2021, 3407. DOI: 10.1002/ejoc.202100580
Transition Metal-Free Regioselective Remote CH Bond 2,2,2-Trifluoroethoxylation of 8-Aminoquinoline Derivatives at the C5 Position

L. Ruyet, M. I. Lapuh, V. S. Koshti, T. Földesi, P. Jubault, T. Poisson, Z. Novák, T. Besset,*
Chem. Commun. 2021, 57, 6241. DOI: 10.1039/d1cc02007b
Z-Selective Pd-catalyzed 2,2,2-trifluoroethylation of acrylamides at room temperature
Invitation for a special Theme Collection “Functionalization of unreactive C-H bonds”
Highlight dans En direct des laboratoires

M. Gao, M. Vuagnat, M.-Y. Chen, X. Pannecoucke, P. Jubault, T. Besset,*
Chem. Eur. J. 2021, 27, 6145. DOI: 10.1002/chem.202004974
Design and Use of Electrophilic Thiocyanating and Selenocyanating Reagents: a New Trend for the Construction of SCN- and SeCN-containing Compounds (Review)
This article also appears in Reviews Showcase

S. Mazeh, I. Lapuh, T. Besset*
CHIMIA 2020, 74, 871. DOI: 10.2533/chimia.2020.871.
Advances in the Synthesis of Fluorinated Scaffolds by Transition Metal-Catalyzed CH Bond Activation (Review)
Invitation for a special issue on ’Innovative Tools in Organic Chemistry’

I. Lapuh, S. Mazeh, T. Besset*
ACS Catal. 2020, 10, 12898. DOI: 10.1021/acscatal.0c03317.
Chiral Transient Directing Groups in Transition-Metal-Catalyzed Enantioselective CH Bond Functionalization (Review)

 

M. Gao, M.-Y. Chen, X. Pannecoucke, P. Jubault, T. Besset,
Chem. Eur. J. 2020, DOI: 10.1002/chem.202003521.
Pd‐Catalyzed Directed Thiocyanation Reaction by C–H Bond Activation
Part of a Special Issue celebrating the 1000th Issue of Chemistry—A European Journal.
This article also appears in: Hot Topic: CH Activation, XXII International Symposium on Homogeneous Catalysis
The Chemistry institute of CNRS spoked of this article (press release by CNRS).

E. Nobile, T. Castanheiro, T. Besset
Angew. Chem. Int. Ed. 2021,60, 12170. DOI: 10.1002/ange.202009995.
Radical‐Promoted Distal CH Functionalization of C(sp3) Centers with Fluorinated Moieties (Review)

M.-Y. Chen, X. Pannecoucke, P. Jubault, T. Besset
Org. Lett. 2020, 22, 7556. DOI: 10.1021/acs.orglett.0c02750.
Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature

L. Ruyet, T. Besset*
Beilstein J. Org. Chem. 2020, 16, 1051. DOI:10.3762/bjoc.16.92.
Copper-based fluorinated reagents for the construction of CF2R-containing molecules (R ≠ F). (Review)
Invited contribution for the “Copper-Catalyzed Reactions for Organic Synthesis” thematic issue of the Beilstein Journal of Organic Chemistry

M. Barday, R. Blieck, L. Ruyet, T. Besset*
Tetrahedron 2020, 76, 131153. DOI: 10.1016/j.tet.2020.131153.
Remote trifluoromethylthiolation of alcohols under visible light.
Invited contribution for the special issue for Nuno Maulide’s Young Investigator Award.

F. Petit-Cancelier, B. François, X. Pannecoucke, S. Couve-Bonnaire, T. Besset*
Adv. Synth. Catal. 2020, 362, 760. DOI:10.1002/adsc.201901454
S-(Diethyl phosphonodifluoromethyl)Benzenesulfonothioate: A New Reagent for the Synthesis of SCF2PO(OEt)2-containing Molecules.

J. Wang, H.-Y. Xiong, E. Petit, L. Bailly, X. Pannecoucke, T. Poisson, T. Besset,*
Chem. Commun. 2019, 55, 8784. DOI: 10.1039/C9CC01851D
BiCl3-Mediated Direct Functionalization of Unsaturated CC Bonds with an Electrophilic SCF2PO(OEt)2 Reagent
Contribution to the Emerging Investigators Issue 2019

E. Carbonnel, T. Poisson, P. Jubault, X. Pannecoucke, T. Besset,*
Front. Chem. 2019, 7, 111. DOI: 10.3389/fchem.2019.
Recent Advances for the Direct Introduction of the CF2Me Moiety.

 

C. Sambiagio, D. Schönbauer, R. Blieck, T. Dao-Huy, G. Pototschnig, P. Schaaf, T. Wiesinger, M. F. Zia, J. Wencel-Delord, T. Besset, B. U. W. Maes, M. Schnürch
Chem. Soc. Rev. 2018, 47, 6603
A comprehensive overview of directing groups applied in metal catalysed CH functionalisation chemistry